DRUG
Pregabalin Clinical Pharmacology Overview Drug Class: Gabapentinoid Indications Neuropathic pain Partial seizures (adjunctive therapy) Generalized anxiety disorder (some regions) Fibromyalgia Mechanism of Action Pregabalin binds to the α2-δ subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. Dosage & Administration Initial dose: 75 mg twice daily Usual dose range: 150–600 mg/day Dose adjustment required in renal impairment Adverse Effects Dizziness Somnolence Peripheral edema Weight gain Conclusion Pregabalin is an effective and well-tolerated treatment for neuropathic pain and seizure disorders when used appropriately and wi...