DRUG

-

Pregabalin

Clinical Pharmacology Overview

Drug Class: Gabapentinoid

Indications

  • Neuropathic pain
  • Partial seizures (adjunctive therapy)
  • Generalized anxiety disorder (some regions)
  • Fibromyalgia

Mechanism of Action

Pregabalin binds to the α2-δ subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P.

Dosage & Administration

  • Initial dose: 75 mg twice daily
  • Usual dose range: 150–600 mg/day
  • Dose adjustment required in renal impairment

Adverse Effects

  • Dizziness
  • Somnolence
  • Peripheral edema
  • Weight gain

Conclusion

Pregabalin is an effective and well-tolerated treatment for neuropathic pain and seizure disorders when used appropriately and with proper dose adjustment.

Thank you

Popular posts from this blog

Trump orders deployment of troops to Portland and authorises 'full force'

-
Image
Trump orders deployment of troops to Portland and authorises 'full force' President Donald Trump has ordered the deployment of US troops to Portland, Oregon, authorising use of "full force" if needed, to suppress protests targeting immigration detention centres. Trump said he was "directing Secretary of War, Pete Hegseth, to provide all necessary Troops to protect War ravaged Portland". He claimed that the move would help protect "any of our ICE Facilities under siege from attack by Antifa, and other domestic terrorists," adding on Truth Social: "I am also authorizing Full Force, if necessary." The announcement drew pushback from Democratic lawmakers, who said there was no need for federal troops to be deployed to the city.
Read more